Nek5 Association with Mitochondria Proteins and Functions: Is It a Nek Family characteristic?
نویسندگان
چکیده
Talita D Melo Hanchuk1 and Jörg Kobarg1,2 * 1Department of Biochemistry and Tissue Biology, State University of Campinas, Campinas, SP, Brazil 2Faculty of Pharmaceutical Sciences, State University of Campinas, Campinas, São Paulo, Brazil *Corresponding author: Jörg Kobarg, Department of Biochemistry and Tissue Biology State University of Campinas, Rua Monteiro Lobato 255, Block F, CEP 13083-862, Campinas SP, Brazil, Tel: 0055-19-3521-1443; E-mail: [email protected]
منابع مشابه
Nek5 promotes centrosome integrity in interphase and loss of centrosome cohesion in mitosis
Nek5 is a poorly characterized member of the NIMA-related kinase family, other members of which play roles in cell cycle progression and primary cilia function. Here, we show that Nek5, similar to Nek2, localizes to the proximal ends of centrioles. Depletion of Nek5 or overexpression of kinase-inactive Nek5 caused unscheduled separation of centrosomes in interphase, a phenotype also observed up...
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